HEMATOLOGIC MALIGNANCY + ONCOLOGY
YEAR 2 | PAGE 25B - LEUKEMIA, LYMPHOMA, PLASMA CELLS + CANCER THERAPY
MALIGNANCY FRAME
Organize by CELL OF ORIGIN -> AGE/PRESENTATION -> CBC/SMEAR -> MARROW/FLOW/CYTOGENETICS -> ORGAN INVOLVEMENT -> EMERGENCY -> THERAPY TARGET. Use molecular findings to explain the phenotype, not as isolated trivia.
B. HEMATOLOGIC MALIGNANCY + ONCOLOGY VIDEOS
| # | Video | Time | Why | Link |
|---|---|---|---|---|
| 1. | Chronic Leukemia | Clinical Medicine - Ninja Nerd | ~1 hr 24 | CML vs CLL, BCR-ABL, immunophenotype, smear patterns, Richter transformation and targeted therapy. | |
| 2. | Lymphoma | Clinical Medicine - Ninja Nerd | ~1 hr 56 | Hodgkin vs NHL subtypes, B symptoms, biopsy/flow, staging, tumor lysis and treatment principles. | |
| 3. | Plasma Cell Disorders | Clinical Medicine - Ninja Nerd | ~1 hr 20 | Multiple myeloma, MGUS and Waldenstrom: CRAB, M-spike, free light chains, marrow findings and therapy. | |
| 4. | Myeloproliferative Neoplasias | Clinical Medicine - Ninja Nerd | ~1 hr 23 | PV, ET, primary myelofibrosis and CML; JAK2/CALR/MPL/BCR-ABL, thrombosis and transformation. | |
| 5. | Antineoplastic Agents | Clinical Medicine - Ninja Nerd | ~3 hr 24 | 2026 deep dive: cell cycle, classic chemotherapy, targeted therapy, immunotherapy, toxicities and rescue logic. | |
| 6. | Oncologic Emergencies | Clinical Medicine - Ninja Nerd | ~2 hr 36 | 2026 review of neutropenic fever, tumor lysis, leukostasis, SVC syndrome, cord compression, hypercalcemia and tamponade. |
B. HEMATOLOGIC MALIGNANCY + ONCOLOGY VIDEOS — ONCOLOGY INTEGRATION CHECK
- Build a one-page ALL/AML/CML/CLL comparison using age, cell lineage, smear/markers, cytogenetics and signature complications. - Compare Hodgkin vs major NHL patterns; know which diagnosis requires excisional biopsy, marrow/flow studies or molecular testing. - Recognize plasma-cell disease from protein + renal/bone/calcium/anemia patterns, not from the name of a monoclonal protein alone. - For antineoplastic drugs, learn TARGET/PHASE -> USE -> SIGNATURE TOXICITY -> MONITORING/RESCUE; recognize oncologic emergencies immediately. VIDEO-FIRST | SCHOOL-EXAM + BOARD-EXAM MASTERY