METABOLIC INTEGRATION + NUTRITION
YEAR 1 | PAGE 10B - GLYCOGEN + PPP + LIPIDS + AMINO ACIDS + NUTRITION
2026 USMLE NUTRITION EMPHASIS
USMLE now lists Nutrition at 15-20% discipline overlap on Step 1 and enhanced nutrition science across all Step exams beginning June 2026. Study vitamins, macro/micronutrients, fed/fasted physiology, malnutrition and metabolic disease as integrated clinical science.
B. METABOLIC-INTEGRATION VIDEOS - DIRECT & PLAYABLE
| # | Video | Time | Why | Link |
|---|---|---|---|---|
| 1. | Pentose Phosphate Pathway - Ninja Nerd | NADPH / G6PD | NADPH, glutathione and ribose-5-phosphate; connect G6PD deficiency, oxidative stress and anabolic metabolism. | Open → |
| 2. | Regulation of Glycogen Metabolism - Ninja Nerd | glycogen | Glycogen synthase/phosphorylase, insulin/glucagon/epinephrine and liver-vs-muscle regulation. | Open → |
| 3. | Fatty Acid Oxidation: Part 1 - Ninja Nerd | beta oxidation | Mobilization, activation, carnitine shuttle and beta-oxidation steps; connect to fasting, hypoglycemia and FA-oxidation disorders. | Open → |
| 4. | Fatty Acid Synthesis: Part 1 - Ninja Nerd | lipogenesis | Acetyl-CoA -> malonyl-CoA, ACC regulation, insulin signaling and the reciprocal relationship with beta oxidation. | Open → |
| 5. | Cholesterol Metabolism - Ninja Nerd | lipids | HMG-CoA reductase, lipoproteins, LDL receptor/HDL transport and the biochemical logic behind dyslipidemia and statins. | Open → |
| 6. | Amino Acid Metabolism - Ninja Nerd | amino acids | Transamination/deamination, nitrogen disposal, urea-cycle integration and glucogenic vs ketogenic carbon skeletons. | Open → |
B. METABOLIC-INTEGRATION VIDEOS - DIRECT & PLAYABLE — INTEGRATION CHECK
- Track carbon and reducing equivalents across carbohydrate, lipid and amino-acid metabolism in fed, fasting and prolonged fasting states.
- Know vitamin/cofactor roles by reaction type and predict the metabolic/neurologic/hematologic consequence of deficiency.
- Connect glycogen, FA-oxidation, urea-cycle and lysosomal disorders to the blocked reaction, accumulated substrate and deficient product.
- Interpret nutrition-related clues: starvation/refeeding, alcohol, malabsorption, bariatric surgery, restrictive diets and micronutrient deficiency. VIDEO-FIRST | SCHOOL-EXAM + BOARD-EXAM MASTERY