HIGH-YIELD STEP 1 + COMLEX REVIEW
YEAR 1-2 | PAGE 10D - BIOCHEMISTRY + NUTRITION BOARD TRANSFER
CURRENT EXAM EMPHASIS
Step 1 currently lists Biochemistry at 5-15% discipline overlap and Nutrition at 15-20%, with 60-70% of items testing application of foundational science. The highest-value review therefore links pathway defects and nutrient states to clinical findings rather than memorizing pathway diagrams alone.
F. HIGH-YIELD PROFESSIONAL-EXAM VIDEOS
| # | Video | Time | Why | Link |
|---|---|---|---|---|
| 1. | Glycogen Storage Diseases - Dirty Medicine | high-yield | High-yield enzyme, organ, lab and presentation patterns for classic GSD vignettes. | Open → |
| 2. | Lysosomal Storage Diseases - High Yield Update - Dirty Medicine | high-yield | Rapid syndrome differentiation with enzyme/substrate/phenotype anchors after organelle biology is understood. | Open → |
| 3. | Urea Cycle - Dirty Medicine | exam review | Exam-focused hyperammonemia logic, urea-cycle enzymes and distinguishing features of major cycle disorders. | Open → |
| 4. | Purine Synthesis - Dirty Medicine | exam review | Synthesis/salvage logic and classic disease/drug associations including HGPRT and ADA pathways. | Open → |
| 5. | Pyrimidine Synthesis - Dirty Medicine | exam review | De novo synthesis and high-yield pathway/drug/disease associations for rapid Step/COMLEX retrieval. | Open → |
| 6. | Fat-Soluble Vitamins - Dirty Medicine | nutrition | Vitamin A/D/E/K deficiency-toxicity patterns and clinical associations relevant to the 2026 nutrition emphasis. | Open → |
G. PRACTICE + READINESS - INTENTIONALLY NOT VIDEO
| Resource | Description | Link |
|---|---|---|
| UWorld Step 1 | Primary transfer layer for metabolic disease, vitamins/nutrition, enzyme deficiencies, toxicology and integrated physiology. | Open → |
| AMBOSS USMLE | Targeted repair of weak pathways, nutrition/vitamin concepts and inborn errors after a question-bank miss. | Open → |
| NBME CBSSA / CBSE | Use recurring official-style misses to decide which pathway or disease cluster needs re-teaching. | Open → |
| TrueLearn + NBOME Level 1 | DO learners: apply the same biochemical mechanisms to COMLEX-style clinical presentations and readiness testing. | Open → |
G. PRACTICE + READINESS - INTENTIONALLY NOT VIDEO — PROFESSIONAL-EXAM MASTERY GATE
Board-ready means you can move from pathway/regulatory defect -> biochemical consequence -> lab/clinical phenotype -> compensatory response, and can recognize nutrition/vitamin risk from the clinical context. Use creator videos to repair specific misses; NBME/COMSAE trends judge readiness. VIDEO-FIRST | SCHOOL-EXAM + BOARD-EXAM MASTERY