| Cardiovascular | Hemodynamics, ischemic disease, heart failure, valves, arrhythmia, congenital disease, vascular disease, cardiovascular drugs. |
| Respiratory | Mechanics/gas exchange, obstructive/restrictive disease, pneumonia, pulmonary vascular disease, neoplasia, respiratory drugs. |
| Renal / Urinary | Filtration/tubules, fluids/electrolytes, acid-base, AKI/CKD, glomerular disease, nephritic/nephrotic syndromes, diuretics. |
| GI / Liver / Nutrition | Motility/absorption, GI pathology, liver/pancreas/biliary disease, nutrition and GI pharmacology. |
| Endocrine / Metabolism | Pituitary, thyroid, adrenal, diabetes, calcium/bone, endocrine pharmacology. |
| Reproductive / Pregnancy Foundations | Male/female reproductive disease, fertility, pregnancy physiology/pathology, breast disease, reproductive pharmacology. |
| Hematology / Oncology | Anemia, bleeding/clotting, leukemias/lymphomas, oncologic principles and therapeutics. |
| Infectious Disease | Syndrome-based infections, antimicrobial selection/resistance and infection prevention. |
| MSK / Rheumatology / Dermatology | Arthritis, autoimmune disease, bone/muscle pathology, dermatologic patterns and related therapies. |
| Neurology / Psychiatry | Localization + neurologic disease, psychiatric diagnosis and psychopharmacology. |
| Integrated Clinical Reasoning | Differential diagnosis, test selection, pretest probability, management sequencing and safety. |