SCHOOL-EXAM + PROBLEM-SOLVING MASTERY
YEAR 1 | PAGE 10C - PATHWAYS, REGULATION, VITAMINS & INBORN ERRORS
C. WHAT SCHOOL EXAMS COMMONLY REQUIRE
| Resource | Description | Link |
|---|---|---|
| Pathway reconstruction | Draw the pathway, identify rate-limiting/irreversible steps, location, cofactors and net ATP/reducing equivalents. | |
| Regulation | Predict pathway direction after insulin, glucagon, epinephrine, fasting, exercise, alcohol, hypoxia or enzyme inhibition. | |
| Enzyme kinetics | Interpret Km/Vmax and inhibitor effects; distinguish kinetic reasoning from simple memorization. | |
| Inborn errors | Blocked enzyme -> accumulated substrate -> deficient product -> organ/system phenotype -> lab clue. | |
| Vitamins/cofactors | Connect cofactor to enzyme family/reaction and to characteristic deficiency or toxicity findings. | |
| Nutrition/metabolic states | Integrate fed/fasted/starved states, malnutrition, refeeding, alcohol metabolism and micronutrient risk. |
D. 7-DAY SCHOOL-EXAM REVIEW CYCLE
| Resource | Description | Link |
|---|---|---|
| Days 1-2 | Carbohydrate/energy metabolism: glycolysis, gluconeogenesis, glycogen, TCA, ETC, PPP and enzyme kinetics. | |
| Days 3-4 | Lipids + amino acids: beta oxidation, synthesis, cholesterol/lipoproteins, nitrogen handling and urea-cycle logic. | |
| Day 5 | Vitamins/cofactors + nutrition + fed/fasted/starvation integration; build one-page mechanism tables from memory. | |
| Day 6 | Timed mixed pathway/case block. Classify every miss: pathway, regulation, cofactor, enzyme deficiency, calculation or integration. | |
| Day 7 | Re-test missed mechanisms on NEW vignettes and pathway prompts; target only remaining weak concepts with video review. |
D. 7-DAY SCHOOL-EXAM REVIEW CYCLE — E. ERROR-LOG TAXONOMY
- Pathway-order gap - knew components but not where they belong or what enters/exits.
- Regulation gap - memorized pathway but could not predict insulin/glucagon/allosteric direction.
- Cofactor/vitamin gap - missed because the vitamin's biochemical role was disconnected from phenotype.
- Inborn-error mechanism gap - recognized the disease but not substrate/product/lab consequences.
- Metabolic-state gap - failed to integrate liver/muscle/adipose/RBC behavior across fed, fasting or alcohol states.
D. 7-DAY SCHOOL-EXAM REVIEW CYCLE — SCHOOL-EXAM GATE
Proceed when you can reproduce the major pathways and regulation without notes, explain the biochemical mechanism behind common deficiencies, and solve unfamiliar integrated cases rather than recalling only named diseases. VIDEO-FIRST | SCHOOL-EXAM + BOARD-EXAM MASTERY