Medical School MD + DO Mastery

A 4-year, board-aligned study system for medical school and licensing exams.

Walk the full Year 1–4 curriculum — foundational sciences, organ-system blocks, clinical clerkships and advanced practice — each with mastery checklists and linked learning resources, plus a dedicated review system for school exams, Shelf/COMAT, USMLE Step 1–3 and COMLEX-USA Levels 1–3.

BIOCHEMISTRY & METABOLISM

YEAR 1 | PAGE 10A - ENZYMES + CARBOHYDRATE / ENERGY METABOLISM

Master each pathway as PURPOSE -> LOCATION -> INPUTS/OUTPUTS -> IRREVERSIBLE/RATE-LIMITING STEP -> REGULATION -> FED/FASTED STATE -> DISEASE/DRUG LINK. Do not memorize enzyme deficiencies before the normal pathway makes sense.

A. DEEP CONCEPT VIDEOS - DIRECT & PLAYABLE

#VideoTimeWhyLink
1.Michaelis-Menten Equation - Ninja Nerdenzyme kineticsKm, Vmax, saturation and inhibitor effects - the quantitative enzyme framework underlying pathway regulation and drug/toxin questions.Open →
2.Glycolysis - Ninja Nerdcore pathwayPathway, enzymes, ATP/NADH accounting and clinical meaning. Draw the entire pathway after the video without notes.Open →
3.Regulation of Glycolysis - Ninja NerdregulationHexokinase/glucokinase, PFK-1, pyruvate kinase and hormonal/allosteric control; connects fed/fasted states to metabolism.Open →
4.Gluconeogenesis - Ninja NerdfastingBypass enzymes, substrates, energetic cost and insulin/glucagon control; compare directly against glycolysis.Open →
5.The Krebs Cycle - Ninja Nerdcore pathwayTCA reactions, regulation, NADH/FADH2 production and integration with amino acids, heme and oxidative metabolism.Open →
6.Electron Transport Chain: Detailed Part 1 - Ninja Nerddeep conceptComplexes I-IV, coenzyme Q, cytochrome c, proton gradient and oxidative phosphorylation - the ATP-production backbone.Open →

A. DEEP CONCEPT VIDEOS - DIRECT & PLAYABLE — ENERGY-METABOLISM CLOSED-BOOK CHECK

  • Draw glycolysis, gluconeogenesis, TCA and ETC from memory with irreversible/rate-limiting steps and major regulators.
  • Explain the fed vs fasting response to insulin/glucagon and why liver, muscle, adipose and RBC metabolism differ.
  • Predict ATP/NADH consequences of pathway blockade, mitochondrial dysfunction, hypoxia or toxin exposure.
  • Interpret enzyme-kinetic curves and distinguish competitive vs noncompetitive inhibition conceptually. VIDEO-FIRST | SCHOOL-EXAM + BOARD-EXAM MASTERY