Medical School MD + DO Mastery

A 4-year, board-aligned study system for medical school and licensing exams.

Walk the full Year 1–4 curriculum — foundational sciences, organ-system blocks, clinical clerkships and advanced practice — each with mastery checklists and linked learning resources, plus a dedicated review system for school exams, Shelf/COMAT, USMLE Step 1–3 and COMLEX-USA Levels 1–3.

IMMUNE DYSFUNCTION + CLINICAL IMMUNOLOGY

YEAR 1 | PAGE 12B - HYPERSENSITIVITY, IMMUNODEFICIENCY, AUTOIMMUNITY & TRANSPLANT

Use mechanism to classify disease: TOO MUCH/WRONG TARGET -> hypersensitivity/autoimmunity; TOO LITTLE -> immunodeficiency; FOREIGN TISSUE -> transplant rejection. Organize every syndrome by the immune arm involved, timing, laboratory pattern and expected infection/injury phenotype.

B. CLINICAL-IMMUNOLOGY VIDEOS - CORE + ENRICHMENT

#VideoTimeWhyLink
1.Type I Hypersensitivity - Osmosis from ElsevierType IIgE sensitization, mast-cell activation, mediators, anaphylaxis and atopy - a concise visual bridge from mechanism to clinical pattern.Open →
2.Type II Hypersensitivity - Osmosis from ElsevierType IIAntibody-mediated cell/tissue injury, complement and receptor effects; connect the mechanism to hemolysis, Goodpasture, Graves and myasthenia.Open →
3.Hypersensitivity Type III - Armando HasudunganType IIIImmune-complex deposition, complement activation and inflammation with classic renal, pulmonary and systemic examples.Open →
4.Approach to Primary Immunodeficiencies - Osmosisclinical frameworkClinical decision-tree approach using age, infection pattern, syndromic clues and immune compartment to differentiate major disorders.Open →
5.Immunodeficiencies: Combined T- and B-cell Disorders - Osmosis~19 minSCID, DiGeorge, Wiskott-Aldrich, ataxia-telangiectasia and other combined defects organized by mechanism and phenotype.Open →
6.Type IV / Delayed Hypersensitivity Clinical Enrichment - Armando HasudunganENRICHMENTT-cell-mediated delayed hypersensitivity applied to drug reactions and inflammatory tissue injury; useful to complete the I-IV framework.Open →

B. CLINICAL-IMMUNOLOGY VIDEOS - CORE + ENRICHMENT — CLINICAL IMMUNOLOGY CHECK

  • Classify Types I-IV by effector, timing, tissue-injury mechanism and classic disease examples.
  • For each primary immunodeficiency: immune defect -> infection pattern -> age/presentation -> key lab -> prevention/treatment principle.
  • Distinguish autoantibody-mediated receptor disease from immune-complex disease and from T-cell-mediated tissue injury.
  • Differentiate hyperacute, acute cellular/antibody-mediated and chronic transplant rejection; separate graft rejection from GVHD. VIDEO-FIRST | SCHOOL-EXAM + BOARD-EXAM MASTERY