HEMODYNAMIC DISORDERS + NEOPLASIA
YEAR 1 | PAGE 15B - THROMBOSIS, EMBOLISM, INFARCTION, SHOCK + CANCER BIOLOGY
TWO CAUSAL CHAINS
Hemodynamics: EDEMA/ENDOTHELIAL INJURY + STASIS + HYPERCOAGULABILITY -> THROMBUS -> EMBOLUS/INFARCT -> SHOCK. Neoplasia: GROWTH-CONTROL/DNA-REPAIR FAILURE -> CLONAL EXPANSION -> INVASION -> METASTASIS -> GRADE/STAGE.
B. HEMODYNAMICS + NEOPLASIA VIDEOS - CORE + ENRICHMENT
| # | Video | Time | Why | Link |
|---|---|---|---|---|
| 1. | Hemostasis: Coagulation Cascade - Ninja Nerd | ~43 min | Primary hemostasis plus intrinsic/extrinsic/common pathways, thrombin/fibrin, PT/aPTT and DIC/bleeding correlations. | |
| 2. | Shock | Clinical Medicine - Ninja Nerd | ~40 min | Hypovolemic, cardiogenic, obstructive and distributive shock integrated with hemodynamics, compensation and organ failure. | |
| 3. | Cell Cycle Regulation - Ninja Nerd | ~40 min | Cyclins/CDKs, checkpoints, growth signals, tumor suppressors and apoptosis - the control-system prerequisite for neoplasia. | |
| 4. | Cancer - Introduction I - Armando Hasudungan | cancer foundations | Oncogenes, tumor suppressors, malignant transformation and the mechanistic foundation of the hallmarks of cancer. | |
| 5. | Cancer - Introduction II - Armando Hasudungan | progression | Tumor growth, angiogenesis, immune interaction, invasion and progression - connect molecular change to malignant behavior. | |
| 6. | Cancer - Metastasis - Armando Hasudungan | spread | Basement-membrane invasion, circulation, colonization and lymphatic vs hematogenous spread in an exam-ready causal sequence. |
B. HEMODYNAMICS + NEOPLASIA VIDEOS - CORE + ENRICHMENT — HEMODYNAMICS / NEOPLASIA INTEGRATION CHECK
- Explain edema from hydrostatic, oncotic, permeability or lymphatic failure and distinguish transudate from exudate.
- Use Virchow triad -> thrombus fate -> embolic destination -> infarct morphology; distinguish major shock patterns.
- Distinguish benign vs malignant, differentiation/anaplasia, dysplasia, invasion, grading and staging.
- Move from oncogene/tumor-suppressor/DNA-repair failure -> cell-cycle consequence -> invasion/metastatic route. VIDEO-FIRST | SCHOOL-EXAM + BOARD-EXAM MASTERY