Medical School MD + DO Mastery

A 4-year, board-aligned study system for medical school and licensing exams.

Walk the full Year 1–4 curriculum — foundational sciences, organ-system blocks, clinical clerkships and advanced practice — each with mastery checklists and linked learning resources, plus a dedicated review system for school exams, Shelf/COMAT, USMLE Step 1–3 and COMLEX-USA Levels 1–3.

ENDOCRINE / METABOLISM

YEAR 2 | PAGE 24A - AXES, FEEDBACK + HORMONE PHYSIOLOGY

BUILD EVERY AXIS AS A CLOSED-LOOP CONTROL SYSTEM

Use HYPOTHALAMUS -> PITUITARY -> TARGET GLAND -> HORMONE EFFECT -> NEGATIVE FEEDBACK. Then add receptor / second messenger, binding protein, circadian or pulsatile release, and the lab pattern produced when the defect is primary vs central.

A. DEEP ENDOCRINE PHYSIOLOGY VIDEOS - DIRECT & PLAYABLE

#VideoTimeWhyLink
1.Hypothalamus: Anterior Pituitary Connection - Ninja Nerddeep conceptPortal circulation, TRH/CRH/GnRH/GHRH/somatostatin/dopamine, anterior pituitary hormones and feedback logic.Open →
2.Hypothalamus: Posterior Pituitary Connection - Ninja Nerddeep conceptADH and oxytocin synthesis/release, supraoptic/paraventricular nuclei, V1/V2 effects and water-balance integration.Open →
3.Synthesis of Thyroid Hormone - Ninja Nerdthyroid physiologyNIS, TPO, organification/coupling, T3/T4 release, TSH feedback and major pharmacologic targets.Open →
4.Adrenal Gland Overview - Ninja Nerdadrenal physiologyZona glomerulosa/fasciculata/reticularis, aldosterone/cortisol/androgens, medullary catecholamines and regulation.Open →
5.Pancreas Overview: Insulin & Glucagon - Ninja Nerdmetabolic controlBeta/alpha cells, fed vs fasting physiology, insulin receptor signaling, glucagon/cAMP and tissue-specific metabolic effects.Open →
6.Parathyroid Gland & Calcitonin - Ninja Nerdcalcium physiologyPTH, vitamin D, renal/bone/intestinal calcium-phosphate control and calcitonin within mineral homeostasis.Open →

A. DEEP ENDOCRINE PHYSIOLOGY VIDEOS - DIRECT & PLAYABLE — ENDOCRINE CLOSED-BOOK CHECK

  • Draw HPT, HPA, HPG, GH/IGF-1 and prolactin axes from memory; predict hormone patterns in primary vs secondary disease.
  • Distinguish peptide/catecholamine vs steroid/thyroid receptor signaling and expected onset/duration of action.
  • Rebuild insulin/glucagon responses across liver, muscle and adipose in fed, fasting and stress states.
  • Predict Ca / phosphate / PTH / vitamin D changes before memorizing named parathyroid disorders. VIDEO-FIRST | SCHOOL-EXAM + BOARD-EXAM MASTERY